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1

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors

Barbosa, Maria Letícia de Castro, Lima, Lídia Moreira, Tesch, Roberta, Sant'Anna, Carlos Mauricio R., Totzke, Frank, Kubbutat, Michael H.G., Schächtele, Christoph, Laufer, Stefan A., Barreiro, Eliezer

Journal:

European Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 2.34 MB

english, 2014

2

Development of First Lead Structures for Phosphoinositide 3-Kinase-C2γ Inhibitors

Freitag, Anne, Prajwal, Prajwal, Shymanets, Aliaksei, Harteneck, Christian, Nürnberg, Bernd, Schächtele, Christoph, Kubbutat, Michael, Totzke, Frank, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2015

3

Cell Lines Expressing Recombinant Transmembrane Domain-Activated Receptor Kinases as Tools for Drug Discovery

Weber, H., Muller, D., Muller, M., Ortiz, A., Birkle, M., Umber, S., Ketterer, C., Siedentopf, O., Feger, D., Totzke, F., Kubbutat, M., Schaechtele, C., Ballmer-Hofer, K., Ehlert, J. E., Graeser, R.

Journal:

Journal of Biomolecular Screening

Année:

2014

Langue:

english

Fichier:

PDF, 642 KB

english, 2014

4

Assessment of heating profiles in model food systems heated by different microwave generators: Solid-state (semiconductor) versus traditional magnetron technology

Taghian Dinani, Somayeh, Kubbutat, Peter, Kulozik, Ulrich

Journal:

Innovative Food Science & Emerging Technologies

Année:

2020

Fichier:

PDF, 2.09 MB

2020

5

Structure-Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone

Conrad Kunick, Zhihong Zeng, Rick Gussio, Daniel Zaharevitz, Maryse Leost, Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Laurent Meijer, Thomas Lemcke

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 283 KB

english, 2005

6

ChemInform Abstract: Dual IGF-1R/SRC Inhibitors Based on a N′-Aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide Structure.

Stefanie Schmidt, Lutz Preu, Thomas Lemcke, Frank Totzke, Christoph Schaechtele, Michael H. G. Kubbutat, Conrad Kunick

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 39 KB

english, 2011

7

Identification of Inhibitors of the Tyrosine Kinase c-Met by Structure-Based Virtual Screening

Thomas Lemcke, Jan Dreher, Matthias Rarey, Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Conrad Kunick

Journal:

Molecular Informatics

Année:

2011

Langue:

english

Fichier:

PDF, 372 KB

english, 2011

8

Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation

Wim Wätjen, Abdessamad Debbab, Anke Hohlfeld, Yvonni Chovolou, Andreas Kampkötter, Ru Angelie Edrada, Rainer Ebel, Abdelhak Hakiki, Mahjouba Mosaddak, Frank Totzke, Michael H. G. Kubbutat, Peter Proks

Journal:

Molecular Nutrition & Food Research

Année:

2009

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2009

9

Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones

Conrad Kunick, Carola Bleeker, Christian Prühs, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Andreas Link

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 137 KB

english, 2006

10

N-substituted 2′-(aminoaryl)benzothiazoles as kinase inhibitors: Hit identification and scaffold hopping

Stefan Tasler, Oliver Müller, Tanja Wieber, Thomas Herz, Rolf Krauss, Frank Totzke, Michael H.G. Kubbutat, Christoph Schächtele

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 3.30 MB

english, 2009

11

Inverse In Silico Screening for Identification of Kinase Inhibitor Targets

Stefan Zahler, Simon Tietze, Frank Totzke, Michael Kubbutat, Laurent Meijer, Angelika M. Vollmar, Joannis Apostolakis

Journal:

Chemistry & Biology

Année:

2007

Langue:

english

Fichier:

PDF, 738 KB

english, 2007

12

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: A new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines

Simone Kohfeld, Peter G. Jones, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick

Journal:

European Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 286 KB

english, 2007

13

Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

Stefanie Schmidt, Lutz Preu, Thomas Lemcke, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick

Journal:

European Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 627 KB

english, 2011

14

Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa

Cui Shi, Min-Juan Xu, Mirko Bayer, Zhi-Wei Deng, Michael H.G. Kubbutat, Wim Waejen, Peter Proksch, Wen-Han Lin

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 468 KB

english, 2010

15

Corrigendum to “Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa” [Phytochemistry 71(4) (2010) 435–442]

Cui Shi, Min-Juan Xu, Mirko Bayer, Zhi-Wei Deng, Michael H.G. Kubbutat, Wim Wätjen, Peter Proksch, Wen-Han Lin

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 104 KB

english, 2010

16

Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization

Stefan Tasler, Oliver Müller, Tanja Wieber, Thomas Herz, Stefano Pegoraro, Wael Saeb, Martin Lang, Rolf Krauss, Frank Totzke, Ute Zirrgiebel, Jan E. Ehlert, Michael H.G. Kubbutat, Christoph Schächtele

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2009

17

Arthrinins A–D: Novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.

Sherif S. Ebada, Barbara Schulz, Victor Wray, Frank Totzke, Michael H.G. Kubbutat, Werner E.G. Müller, Alexandra Hamacher, Matthias U. Kassack, Wenhan Lin, Peter Proksch

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 337 KB

english, 2011

18

10.1038/35004057

Vousden, Karen H., Lohrum, Marion A. E., Ashcroft, Margaret, Kubbutat, Michael H. G.

Journal:

Nature Cell Biology

Année:

2000

Langue:

english

Fichier:

PDF, 225 KB

english, 2000

19

Regulation of p53 stability by Mdm2

Kubbutat, Michael H. G., Jones, Stephen N., Vousden, Karen H.

Journal:

Année:

1997

Fichier:

PDF, 3.48 MB

1997

20

2-Anilino-4-(benzimidazol-2-yl)pyrimidines – A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

Renate Determann, Jan Dreher, Knut Baumann, Lutz Preu, Peter G. Jones, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick

Journal:

European Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 646 KB

english, 2012

21

Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-k B signalling in H4IIE cells

Wim Wätjen, Annika Putz, Yvonni Chovolou, Andreas Kampkötter, Frank Totzke, Michael H.G. Kubbutat, Peter Proksch, Belma Konuklugil

Journal:

Journal of Pharmacy and Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 376 KB

english, 2009

22

Workflow Comparison for Label-Free, Quantitative Secretome Proteomics for Cancer Biomarker Discovery: Method Evaluation, Differential Analysis, and Verification in Serum

Piersma, Sander R., Fiedler, Ulrike, Span, Simone, Lingnau, Andreas, Pham, Thang V., Hoffmann, Steffen, Kubbutat, Michael H. G., Jiménez, Connie R.

Journal:

Journal of Proteome Research

Année:

2010

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2010

23

Decalactone Derivatives from Corynespora cassiicola, an Endophytic Fungus of the Mangrove Plant Laguncularia racemosa

Weaam Ebrahim, Amal H. Aly, Attila Mándi, Frank Totzke, Michael H. G. Kubbutat, Victor Wray, Wen-Han Lin, Haofu Dai, Peter Proksch, Tibor Kurtán, Abdessamad Debbab

Journal:

European Journal of Organic Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 582 KB

english, 2012

24

Contribution of two independent MDM2-binding domains in p14ARF to p53 stabilization

Marion A.E. Lohrum, Margaret Ashcroft, Michael H.G. Kubbutat, Karen H. Vousden

Journal:

Current Biology

Année:

2000

Langue:

english

Fichier:

PDF, 98 KB

english, 2000

25

Keeping an old friend under control: regulation of p53 stability

Michael H.G Kubbutat PhD, Karen H Vousden PhD

Journal:

Molecular Medicine Today

Année:

1998

Langue:

english

Fichier:

PDF, 119 KB

english, 1998

26

Regulation of HDM2 activity by the ribosomal protein L11

Marion A.E Lohrum, Robert L Ludwig, Michael H.G Kubbutat, Mary Hanlon, Karen H Vousden

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 435 KB

english, 2003

27

Comparison of monoclonal antibodies PC 10 and MIB 1 on microwave-processed paraffin sections

M. H. G. Kubbutat, G. Cattoretti, J. Gerdes, G. Key

Journal:

Cell Proliferation

Année:

1994

Langue:

english

Fichier:

PDF, 456 KB

english, 1994

28

A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries

Angelika Oehmig, Andrea Klotzbücher, Maria Thomas, Frank Weise, Ursula Hagner, Ralf Brundiers, Dirk Waldherr, Andreas Lingnau, Achim Knappik, Michael HG Kubbutat, Thomas O Joos, Hansjürgen Volkmer

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 3.82 MB

english, 2008

29

ChemInform Abstract: 2-Anilino-4-(benzimidazol-2-yl)pyrimidines — A Multikinase Inhibitor Scaffold with Antiproliferative Activity Toward Cancer Cell Lines.

Renate Determann, Jan Dreher, Knut Baumann, Lutz Preu, Peter G. Jones, Frank Totzke, Christoph Schaechtele, Michael H. G. Kubbutat, Conrad Kunick

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 32 KB

english, 2012

30

Role of E6 and E7 oncoproteins in HPV-induced anogenital malignancies

Michael H.G. Kubbutat, Karen H. Vousden

Journal:

Seminars in Virology

Année:

1996

Langue:

english

Fichier:

PDF, 102 KB

english, 1996

31

1251 POSTER Preclinical and Clinical Development of 4SC-203 – a Novel Multi-target Kinase Inhibitor

R. Krauss, F. Wagner, R. Doblhofer, B. Dietrich, J. Ehlert, M.H.G. Kubbutat, A. Lingnau, F. Totzke, C. Schachtele, B. Hentsch

Journal:

European Journal of Cancer

Année:

2011

Langue:

english

Fichier:

PDF, 44 KB

english, 2011

32

New HPV E6 binding proteins: dangerous liaisons?

Michael H.G Kubbutat, Karen H Vousden

Journal:

Trends in Microbiology

Année:

1998

Langue:

english

Fichier:

PDF, 117 KB

english, 1998

33

Cause and consequence of becoming persistent: Persistent Viral Infections edited by R. Ahmed and I.S.Y. Chen

Michael H.G Kubbutat

Journal:

Trends in Microbiology

Année:

1999

Langue:

english

Fichier:

PDF, 80 KB

english, 1999

34

Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum Isolated from Mentha pulegium

Debbab, Abdessamad, Aly, Amal H., Edrada-Ebel, RuAngelie, Wray, Victor, Müller, Werner E. G., Totzke, Frank, Zirrgiebel, Ute, Schächtele, Christoph, Kubbutat, Michael H. G., Lin, Wen Han, Mosaddak,

Journal:

Journal of Natural Products

Année:

2009

Langue:

english

Fichier:

PDF, 102 KB

english, 2009

35

Assessing the Target Differentiation Potential of Imidazole-Based Protein Kinase Inhibitors

Dimova, Dilyana, Iyer, Preeti, Vogt, Martin, Totzke, Frank, Kubbutat, Michael H. G., Schächtele, Christoph, Laufer, Stefan, Bajorath, Jürgen

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 622 KB

english, 2012

36

Trimeric Hemibastadin Congener from the Marine Sponge Ianthella basta

Niemann, Hendrik, Lin, Wenhan, Müller, Werner E. G., Kubbutat, Michael, Lai, Daowan, Proksch, Peter

Journal:

Journal of Natural Products

Année:

2013

Langue:

english

Fichier:

PDF, 939 KB

english, 2013

37

Assessment of cell proliferation by means of an enzyme-linked immunosorbent assay based on the detection of the Ki-67 protein

Göran Key, Michael H.G. Kubbutat, Johannes Gerdes

Journal:

Journal of Immunological Methods

Année:

1994

Langue:

english

Fichier:

PDF, 385 KB

english, 1994

38

Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases

Thaher, Bassam Abu, Arnsmann, Martina, Totzke, Frank, Ehlert, Jan E., Kubbutat, Michael H. G., Schächtele, Christoph, Zimmermann, Markus O., Koch, Pierre, Boeckler, Frank M., Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.82 MB

english, 2012

39

Cytotoxic Metabolites from the Fungal Endophyte Alternaria sp. and Their Subsequent Detection in Its Host Plant Polygonum senegalense

Aly, Amal H., Edrada-Ebel, RuAngelie, Indriani, Ine Dewi, Wray, Victor, Müller, Werner E. G., Totzke, Frank, Zirrgiebel, Ute, Schächtele, Christoph, Kubbutat, Michael H. G., Lin, W. H., Proksch, Pet

Journal:

Journal of Natural Products

Année:

2008

Langue:

english

Fichier:

PDF, 182 KB

english, 2008

40

Search for Inhibitors of Bacterial and Human Protein Kinases among Derivatives of Diazepines[1,4] Annelated with Maleimide and Indole Cycles

Danilenko, Valery N., Simonov, Alexander Y., Lakatosh, Sergey A., Kubbutat, Michael H. G., Totzke, Frank, Schächtele, Christoph, Elizarov, Sergey M., Bekker, Olga B., Printsevskaya, Svetlana S., Luzi

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 514 KB

english, 2008

41

Cytotoxic and Protein Kinase Inhibiting Nakijiquinones and Nakijiquinols from the Sponge Dactylospongia metachromia

Daletos, Georgios, de Voogd, Nicole J., Müller, Werner E. G., Wray, Victor, Lin, WenHan, Feger, Daniel, Kubbutat, Michael, Aly, Amal H., Proksch, Peter

Journal:

Journal of Natural Products

Année:

2014

Langue:

english

Fichier:

PDF, 642 KB

english, 2014

42

173 Analysis of Cellular Kinase Activity of Resistance-related EGFR Mutants Using Transmembrane-Domain (TMD) Activated Kinase Variants

Weber, H., Müller, D., Totzke, F., Müller, M., Siedentopf, O., Kubbutat, M.H.G., Graeser, R., Feger, D., Schaechtele, C., Ehlert, J.E.

Journal:

European Journal of Cancer

Année:

2012

Langue:

english

Fichier:

PDF, 56 KB

english, 2012

43

170 A High-throughput Capable Method to Identify Allosteric Inhibitors of Protein Kinase Activation Cascades

Müller, D., Totzke, F., Beisenherz-Huss, C., Heidemann-Dinger, C., Ketterer, C., Krämer, D., Weber, T., Kubbutat, H.G.

Journal:

European Journal of Cancer

Année:

2012

Langue:

english

Fichier:

PDF, 59 KB

english, 2012

44

Identification of 2-Anilino-9-methoxy-5,7-dihydro-6 H -pyrimido[5,4- d ][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead Generation

Egert-Schmidt, Anne-Marie, Dreher, Jan, Dunkel, Ute, Kohfeld, Simone, Preu, Lutz, Weber, Holger, Ehlert, Jan E., Mutschler, Bettina, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H. G., Bau

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 3.10 MB

english, 2010

45

A Novel Roscovitine Derivative Potently Induces G1-Phase Arrest in Platelet-Derived Growth Factor-BB-Activated Vascular Smooth Muscle Cells

Sroka, I. M., Heiss, E. H., Havlicek, L., Totzke, F., Aristei, Y., Pechan, P., Kubbutat, M. H. G., Strnad, M., Dirsch, V. M.

Journal:

Molecular Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 1.99 MB

english, 2010

46

17 Studies on glycoprotein expression differences between MCF-7 and MCF-7-Z

Ner-Kluza, J., Drabik, A., Kubbutat, M., Lingnau, A., Silberring, J.

Journal:

European Journal of Cancer

Année:

2014

Langue:

english

Fichier:

PDF, 59 KB

english, 2014

47

331 Biomarker discovery and validation for assessing the response to cMet inhibition and functional inactivation

Jung, S., Selzer, S., Loβner, C., Kuhn, K., Fiedler, U., KlotzbUcher, A., Zucht, H.D., Koncarevic, S., Prinz, T., Hertfelder, D., Boehme, K.A., Volkmer, H., Kubbutat, M.H.G., Budde, P., Pike, I.

Journal:

European Journal of Cancer

Année:

2014

Langue:

english

Fichier:

PDF, 58 KB

english, 2014

48

Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells

Limper, Christian, Wang, Yao, Ruhl, Sven, Wang, Zhiqiang, Lou, Yijia, Totzke, Frank, Kubbutat, Michael H.G., Chovolou, Yvonni, Proksch, Peter, Wätjen, Wim

Journal:

Journal of Pharmacy and Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 1010 KB

english, 2013

49

Meriolins, a New Class of Cell Death Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases

Bettayeb, K., Tirado, O. M., Marionneau-Lambot, S., Ferandin, Y., Lozach, O., Morris, J. C., Mateo-Lozano, S., Drueckes, P., Schachtele, C., Kubbutat, M. H.G., Liger, F., Marquet, B., Joseph, B., Echa

Journal:

Cancer Research

Année:

2007

Langue:

english

Fichier:

PDF, 973 KB

english, 2007

50

Apoptosis and Its Relevance in Cancer Therapy

Ehlert, J.E., Kubbutat, M.H.G.

Journal:

Année:

2001

Fichier:

PDF, 128 KB

2001